Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Few dishes strike the perfect balance between bold flavor and creamy comfort quite like creamy Cajun chicken spaghetti with garlic mozzarella sauce. This recipe delivers tender, spice-rubbed chicken, silky strands of spaghetti, and a rich garlic-infused mozzarella cream sauce that clings to every bite. It’s indulgent, satisfying, and bursting with Southern-inspired flavor—yet simple enough to make on a busy weeknight.

Cajun cuisine is known for its warmth, depth, and unapologetic seasoning. When paired with a creamy pasta base, those bold spices mellow into something incredibly crave-worthy. The garlic mozzarella sauce softens the heat just enough, creating a luxurious texture that feels restaurant-quality without requiring advanced cooking skills.

Whether you’re feeding a hungry family, cooking for guests, or just treating yourself to comfort food with attitude, this cajun chicken spaghetti deserves a permanent spot in your dinner rotation.

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Why This Cajun Chicken Spaghetti Works So Well

This recipe isn’t just creamy—it’s thoughtfully balanced. Each element plays a role:

• Cajun-seasoned chicken adds smoky heat and protein
• Garlic mozzarella sauce delivers rich, melty creaminess
• Spaghetti noodles soak up every drop of sauce
• Parmesan and butter deepen flavor without overpowering

Unlike heavier cream sauces that can feel flat, this one stays dynamic thanks to garlic, spices, and slow melting cheese. The result is comfort food that feels indulgent but never boring.

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What Makes Cajun Pasta So Popular?

Cajun pasta recipes have gained massive popularity because they blend bold spices with creamy textures. Traditionally rooted in Louisiana cooking, Cajun seasoning typically includes paprika, garlic powder, onion powder, cayenne, black pepper, and herbs.

When paired with cream-based sauces, Cajun spices transform from fiery to savory. That’s why dishes like creamy cajun chicken pasta are beloved by spice lovers and comfort-food fans alike.

This version leans into that balance, delivering warmth without overwhelming heat—perfect for a wide range of palates.

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Ingredients You’ll Need

For the Cajun Chicken:

• Boneless, skinless chicken breasts
• Cajun seasoning
• Paprika
• Garlic powder
• Olive oil
• Salt and black pepper

For the Pasta and Sauce:

• Spaghetti pasta
• Unsalted butter
• Fresh garlic cloves, minced
• Heavy cream
• Whole milk
• Shredded mozzarella cheese
• Freshly grated Parmesan cheese
• Crushed red pepper flakes (optional)
• Fresh parsley for garnish

Each ingredient builds on the last, creating layers of flavor rather than a single-note cream sauce.

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Step-by-Step Instructions

1. Cook the spaghetti
   Bring a large pot of salted water to a boil. Cook spaghetti according to package instructions until al dente. Reserve ½ cup pasta water, then drain and set aside.
2. Season the chicken
   Pat chicken breasts dry and season generously with Cajun seasoning, paprika, garlic powder, salt, and pepper.
3. Cook the chicken
   Heat olive oil in a large skillet over medium-high heat. Cook chicken for 5–6 minutes per side until golden and fully cooked. Remove from skillet and let rest before slicing.
4. Make the garlic base
   Reduce heat to medium. Add butter to the same skillet. Once melted, add minced garlic and sauté for 30–60 seconds until fragrant.
5. Build the cream sauce
   Slowly pour in heavy cream and milk, stirring constantly. Bring to a gentle simmer—do not boil.
6. Add the cheese
   Stir in mozzarella and Parmesan a little at a time, allowing each addition to melt fully before adding more. Sauce should become smooth and glossy.
7. Season the sauce
   Taste and adjust with salt, pepper, Cajun seasoning, or red pepper flakes as desired.
8. Combine pasta and sauce
   Add cooked spaghetti directly into the sauce, tossing gently to coat. Use reserved pasta water to loosen sauce if needed.
9. Add chicken
   Slice chicken and return it to the skillet, folding it into the pasta.
10. Finish and serve
    Garnish with fresh parsley and extra Parmesan. Serve hot.

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Pro Tips for Perfect Creamy Cajun Pasta

• Don’t overcook the chicken—juicy chicken keeps the dish tender.
• Grate cheese fresh for smoother melting.
• Keep heat low when adding cheese to prevent grainy sauce.
• Reserve pasta water—it’s liquid gold for creamy sauces.

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Variations and Customizations

This recipe is incredibly adaptable:

• Spicy version: Add extra cayenne or hot sauce.
• Veggie-loaded: Stir in sautéed bell peppers, spinach, or mushrooms.
• Protein swap: Use shrimp or smoked sausage instead of chicken.
• Lighter option: Substitute half-and-half for heavy cream.

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What to Serve with Cajun Chicken Spaghetti

Pair this rich pasta with lighter sides for balance:

• Garlic bread or breadsticks
• Simple green salad with vinaigrette
• Roasted broccoli or asparagus
• Lemon cucumber salad

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Storage and Reheating

Storage:
Store leftovers in an airtight container in the refrigerator for up to 4 days.

Reheating:
Reheat gently on the stovetop or microwave with a splash of milk or cream to loosen the sauce.

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Why This Recipe Is a Weeknight Winner

Despite its indulgent flavor, this creamy cajun chicken spaghetti with garlic mozzarella sauce comes together in under 45 minutes. It uses pantry spices, simple dairy, and one main skillet—making cleanup easy and stress-free.

It’s the kind of meal that feels special without requiring special effort.

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Final Thoughts

If you love bold flavors wrapped in creamy comfort, this dish is for you. Creamy Cajun chicken spaghetti with garlic mozzarella sauce is rich, cozy, slightly spicy, and endlessly satisfying. It’s a recipe that turns an ordinary night into something memorable—and one your readers will come back to again and again.